Transcription profiling of mouse skins of embryos lacking Grainyhead-like epithelial transactivator (Get-1)

ABSTRACT: Defective permeability barrier is an important feature of many skin diseases and causes mortality in premature infants. To investigate the control of barrier formation, we characterized the epidermally expressed Grainyhead-like epithelial transactivator (Get-1)/Grhl3, a conserved mammalian homologue of Grainyhead, which plays important roles in cuticle development in Drosophila. Get-1 interacts with the LIM-only protein LMO4, which is co-expressed in the developing mammalian epidermis. The epidermis of Get-1(-/-) mice showed a severe barrier function defect associated with impaired differentiation of the epidermis, including defects of the stratum corneum, extracellular lipid composition and cell adhesion in the granular layer. The Get-1 mutation affects multiple genes linked to terminal d

ORGANISM(S): Mus musculus

SUBMITTER: Kevin Lin 

PROVIDER: E-GEOD-7381 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress