Gene expression in neonatal NKT cells and lymphoma samples from mice with high E protein levels [Microarray Expression]

ABSTRACT: Inhibitor of DNA binding proteins (ID), including Id1-4, are transcriptional regulators involved in promoting cell proliferation and survival in various cell types. Although upregulation of Id proteins have been widely reported to be associated with a broad spectrum of tumors, recent studies have identified that Id3 also plays a tumor suppressor role in the development of Burkittâ??s lymphoma in humans and Hepatosplenic T cell lymphomas in mice. However, there is a lack of evidence to suggest the tumor suppressor roles for other Id genes, particularly Id2, which is highly expressed in many T lymphocytes. In this study we report that Id2 plays a tumor suppressive role in collaboration with Id3 in developing T cells in mice. We found that there was rapid lymphoma development in Id2f/fId3f/fL

ORGANISM(S): Mus musculus

SUBMITTER: Yuan Zhuang 

PROVIDER: E-GEOD-73864 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress