On the relationship of protein and mRNA dynamics in vertebrate embryonic development [RiboZero]

ABSTRACT: A biochemical explanation of development from the fertilized egg to the adult anatomy requires an understanding of the complement of proteins and RNAs expressed over time during embryogenesis. Here we present a comprehensive characterization of protein and mRNA dynamics across early development in Xenopus. Surprisingly, we find that most proteins change very little and duplicated genes are expressed similarly. While the correlation between mRNA levels and protein expression is poor, a mass action kinetics model parametrized by the protein synthesis and degradation rates regresses protein dynamics to RNA dynamics, corrected for initial protein concentration. This study provides a rich resource for developmental biologists, unveiling detailed data for absolute levels of ~10K proteins and ~28

ORGANISM(S): Xenopus laevis

SUBMITTER: Esther Pearl 

PROVIDER: E-GEOD-73904 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress