Gene expression data from acetaminophen-induced toxicity in human hepatic in vitro systems and clinical liver samples

ABSTRACT: In this study we conducted transcriptomics analyses of: (i) liver samples from patients suffering from acetaminophen-induced acute liver failure (n=3) and from healthy livers (n=2) and (ii) hepatic cell systems exposed to acetaminophen, including their respective vehicle controls. The investigated in vitro systems are: HepaRG cells, HepG2 cells and a novel human skinpostnatal stem cell-derived model i.e. human skin-precursors-derived hepatocyte-like cells (hSKP-HPC). Clinical samples were obtained after surgical removal of the explant liver of patients diagnosed with ALF due to acetaminophen intoxication and treated by orthotopic liver transplantation (n=3). Samples from healthy livers were obtained from individuals deceased from brain damage (n=2). Different samples of hSKP, HepG2 and He

ORGANISM(S): Homo sapiens

SUBMITTER: Robim Rodrigues 

PROVIDER: E-GEOD-74000 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress