Functional tissue specific MSC in lung-transplanted patients with and without bronchiolitis obliterans syndrome (BOS) - a potential source for cell-therapy?

ABSTRACT: Background: Mesenchymal stromal cells (MSC) have been proposed as a future cell based therapy for lung diseases like bronchiolitis obliterans syndrome (BOS). Theoretically, it might be beneficial to use lung resident MSC already adapted to the pulmonary environment. We therefore aimed to compare lung MSC with the well-characterized bone marrow MSC. Furthermore, MSC isolated from lung-transplanted patients with BOS were compared to MSC isolated from good outcome recipients. Methods: MSC were isolated from bone marrow (BM) and adult/fetal lung tissues and compared by a comprehensive panel of assays. Results:The gene expression profiles of adult lung derived and fetal lung derived MSC were very similar compared to BM derived MSC, with only 235 and 338 genes, respectively, being significantly

ORGANISM(S): Homo sapiens

SUBMITTER: Sara Rolandsson Enes 

PROVIDER: E-GEOD-74163 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress