Effect of retinoic acid on gene expression in CD4 cells stimulated with anti CD3 and CD28

ABSTRACT: RNA extracted from CD4 cells was analyzed using affymetrix gene array chips.Data set includes analysis of RNA from DMSO or ATRA treated samples. ATRA induced the expression of a number of genes including LZTFL1. Retinoic acids, which are metabolites of vitamin A, have been shown to be involved in multiple T cell effector responses through their binding to the retinoic acid receptor, a ligand-activated transcription factor. Because the molecular mechanism of regulation by retinoic acid is still not fully uncovered, we investigated the gene expression profile of all-trans retinoic acid (ATRA)-treated human CD4(+) T cells. Leucine zipper transcription factor-like 1 (LZTFL1) was upregulated by ATRA in a dose- and time-dependent manner. The expression of LZTFL1 depended on both ATRA and TCR si

ORGANISM(S): Homo sapiens

SUBMITTER: Ven Natarajan 

PROVIDER: E-GEOD-74280 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress