The CaSm (LSm1) oncogene promotes transformation, chemoresistance, and metastasis of pancreatic cancer cells

ABSTRACT: The Cancer associated Sm-like (CaSm) oncogene is overexpressed in 87% of human pancreatic tumor samples and CaSm knockdown has demonstrated therapeutic efficacy in murine models of pancreatic cancer. Evidence indicates that CaSm modulates mRNA degradation; however, its target genes and the mechanisms by which CaSm promotes pancreatic cancer remain largely unknown. Here, we demonstrate that the CaSm overexpression alters several hallmarks of cancer – including transformation, proliferation, chemoresistance, and metastasis. Doxycycline-induced CaSm expression enhanced proliferation and both anchorage-dependent and -independent growth of the human Panc-1 cells in vitro. CaSm induction decreased gemcitabine-induced cytotoxicity and altered the expression of apoptotic regulation genes, incl

ORGANISM(S): Homo sapiens

SUBMITTER: Elizabeth Little 

PROVIDER: E-GEOD-74319 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress