Comprehensive nucleosome mapping of the human genome in cancer progression

ABSTRACT: Altered chromatin structure is a hallmark of cancer, and inappropriate regulation of chromatin structure may represent the origin of transformation. Several important studies have mapped human nucleosome distributions genome wide, but the genome-wide role of chromatin structure in cancer progression has not been addressed. We developed a MNase-Sequence Capture method, mTSS-seq, to map genome-wide nucleosome distribution in primary human lung and colon adenocarcinoma tissue. Here, we confirm that nucleosome redistribution is an early, widespread event in lung (LAC) and colon (CRC) adenocarcinoma. These altered nucleosome architectures are consistent between LAC and CRC patient samples indicating that they may serve as important early adenocarcinoma markers. We demonstrate that the nucleoso

ORGANISM(S): Homo sapiens

SUBMITTER: Brooke Druliner 

PROVIDER: E-GEOD-74340 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress