The differential expression of mRNAs and long noncoding RNAs between ectopic and eutopic endometrium of adenomyosis

ABSTRACT: Adenomyosis, defined as ectopic endometrial tissue within the myometrium, can often be misdiagnosed as multiple uterine leiomyomata or endometrial thickening. We therefore performed a combined mRNA and long noncoding (lnc)RNA microarray and bioinformatic analysis of eutopic and ectopic endometrium in women with adenomyosis to better understand its pathogenesis and help in the development of a semi-invasive diagnostic test. A total of 586 mRNAs were increased and 305 mRNAs decreased in ectopic endometrium of adenomyosis compared with eutopic endometrium, while 388 lncRNA transcripts were up-regulated and 188 down-regulated in ectopic compared with paired eutopic endometrial tissue. Bioinformatic analysis suggested a series of metabolic and molecular abnormalities in adenomyosis,

ORGANISM(S): Homo sapiens

SUBMITTER: Cheng Zhou 

PROVIDER: E-GEOD-74373 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress