Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Oliver Rando
PROVIDER: E-GEOD-74537 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Science (New York, N.Y.) 20151231 6271
Several recent studies link parental environments to phenotypes in subsequent generations. In this work, we investigate the mechanism by which paternal diet affects offspring metabolism. Protein restriction in mice affects small RNA (sRNA) levels in mature sperm, with decreased let-7 levels and increased amounts of 5' fragments of glycine transfer RNAs (tRNAs). In testicular sperm, tRNA fragments are scarce but increase in abundance as sperm mature in the epididymis. Epididymosomes (vesicles tha ...[more]