Transcriptional Activity in Lymph Nodes During the Initiation and Progression of Autoimmune Encephalomyelitis

ABSTRACT: NOD mice (8- to 13-wk-old) were bred and maintained at the La Trobe University Central Animal House (Bundoora, Melbourne, Australia). All experiments were conducted in accordance with the Australian code of practice for the care and use of animals for scientific purposes (National Health and Medical Research Council 1997), after approval by the La Trobe University Animal Ethics committee (Melbourne, Australia). A total of 124 female mice were divided into three groups. The immunized group comprised 91 mice injected s.c. into the lower flanks with 200 micrograms of MOG35-55 peptide (MEVGWYRSPFSRVVHLYRNGK; Auspep) emulsified in CFA containing 4 mg/ml Mycobacterium tuberculosis (Difco). An i.v. injection of 350 ng of Bordetella pertussis toxin was administered both immediately thereafter and

ORGANISM(S): Mus musculus

SUBMITTER: Sergio Baranzini 

PROVIDER: E-GEOD-7461 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress