Acutely isolated murine cortical astrocytes and microglia: Alzheimer's disease vs wildtype

ABSTRACT: Isolation of glia from Alzheimer's mice reveals inflammation and dysfunction. Reactive astrocytes and microglia are associated with amyloid plaques in Alzheimer's disease (AD). Yet, not much is known about the molecular alterations underlying this reactive phenotype. To get an insight into the molecular changes underlying AD induced astrocyte and microglia reactivity, we performed a transcriptional analysis on acutely isolated astrocytes and microglia from the cortex of aged controls and APPswe/PS1dE9 AD mice. As expected, both cell types acquired a proinflammatory phenotype, which confirms the validity of our approach. Interestingly, we observed that the immune alteration in astrocytes was relatively more pronounced than in microglia. Concurrently, our data reveal that astrocytes display

ORGANISM(S): Mus musculus

SUBMITTER: Elly Hol 

PROVIDER: E-GEOD-74615 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress