The transcription factor BACH2 is required to establish immunosuppression within tumors

ABSTRACT: Through a diversity of functional lineages, cells of the innate and adaptive immune system either drive or constrain immune reactions within tumors. Thus, while the immune system has a powerful ability to recognize and kill cancer cells, this function is often suppressed preventing clearance of disease. The transcription factor (TF) BACH2 controls the differentiation and function of multiple innate and adaptive immune lineages, but its role in regulating tumor immunity is not known. Here, we demonstrate that BACH2 is required to establish immunosuppression within tumors. We found that growth of subcutaneously implanted tumors was markedly impaired in Bach2-deficient mice and coincided with intratumoral activation of both innate and adaptive immunity but was dependent upon adaptive immunity

ORGANISM(S): Mus musculus

SUBMITTER: PING JIN 

PROVIDER: E-GEOD-74653 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress