SCL and LMO1 reprogram thymocytes into self-renewing cells.

ABSTRACT: The SCL and LMO1 oncogenic transcription factors reprogram thymocytes into self-renewing pre-leukemic stem cells (pre-LSCs). Here we report that SCL directly interacts with LMO1 to activate the transcription of a self-renewal program coordinated by LYL1. Gene expression profiles of thymocytes from SCL-LMO1 transgenic and age-matched non transgenic Cd3ε-/- mice were compared to identify candidate genes that confer self-renewal capability to pre-leukemic thymocytes.

ORGANISM(S): Mus musculus

SUBMITTER: Mathieu Tremblay 

PROVIDER: E-GEOD-74659 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress