Environmental enteric dysfunction includes a broad spectrum of inflammatory responses and epithelial repair processes.

ABSTRACT: Environmental enteric dysfunction (EED), a chronic diffuse inflammation of the small intestine, is associated with stunting in children in the developing world. The pathobiology of EED is poorly understood because of the lack of a method to elucidate the host response. This study utilized a novel microarray method to interrogate the host transcriptome in feces in Malawian children with EED. Our data showed that the children studied had a range of %L values, consistent a spectrum of EED from normal to severe. We identified 12 transcripts associated with the severity of EED, including chemokines that stimulate T-cell proliferation, Fc fragments of multiple immunoglobulin families, interferon-induced proteins, activators of neutrophils and B-cells, and mediators that dampen cellular response

ORGANISM(S): Homo sapiens

SUBMITTER: Jinsheng Yu 

PROVIDER: E-GEOD-74681 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress