LY75 modulates epithelial to mesenchymal transition and metastatic potential of ovarian cancer cells

ABSTRACT: Epithelial ovarian cancer (EOC) accounts for 4% of all cancers in women and is the leading cause of death from gynecologic malignancies. It is well established that cancer invasion and metastasis still represent the major causes of the failure of cancer treatment. Previously, we identified the mannose receptor LY75 (DEC205/CD205) gene as notably hypomethylated in high-grade (HG) serous epithelial ovarian tumors, compared to normal ovarian tissues. LY75 has been identified as a putative antigen-uptake receptor, which is expressed abundantly on dendritic cells, which are specialist antigen presenting cells to T lymphocytes for the initiation of an immune response. The implication of LY75 in EOC tumorigenesis is currently unknown. Here we show that LY75 is strongly overexpressed in HG serous

ORGANISM(S): Homo sapiens

SUBMITTER: Dimcho Bachvarov 

PROVIDER: E-GEOD-74711 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress