Pervasive polymorphic imprinted methylation in the human placenta

ABSTRACT: The maternal and paternal copies of the genome are both required for mammalian development and this is primarily due to imprinted genes, those that are mono-allelically expressed based on parent-of-origin. Typically, this pattern of expression is regulated by differentially methylated regions (DMRs) that are established in the germline and maintained after fertilisation. There are a large number of germline DMRs that have not yet been associated with imprinting and their function in development is unknown. In this study, we developed a genome-wide approach to identify novel imprinted DMRs, specifically in the human placenta, and investigated the dynamics of imprinted DMRs during development in somatic and extra-embryonic tissues. DNA methylation was evaluated using the Illumina HumanMet

ORGANISM(S): Homo sapiens

SUBMITTER: Wendy Robinson 

PROVIDER: E-GEOD-74738 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress