H3K36ac is an evolutionary conserved histone modification that marks active genes in plants

ABSTRACT: In eukaryotic cells, DNA is tightly packed in the nucleus in chromatin which has histones as its main protein component. Histones are subject to a large number of distinct post-translational modifications, whose sequential or combinatorial action affects genome function. Here, we report the identification of acetylation at lysine 36 in histone H3 (H3K36ac) as a modification in Arabidopsis thaliana. H3K36ac was found to be an evolutionary conserved modification in seed plants. It is highly enriched in euchromatin and very low in heterochromatin. Genome-wide ChIP-seq experiments revealed that H3K36ac is generally found at the 5â?? end of genes. Independently of gene length, H3K36ac covers about 500 bp, about two to three nucleosomes, immediately downstream of the transcriptional start. H3K36

ORGANISM(S): Arabidopsis thaliana

SUBMITTER: Minerva Trejo Arellano 

PROVIDER: E-GEOD-74841 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress