Transcriptome Analysis of Developing Intestine [RNA-Seq]

ABSTRACT: Background: The muscularis externa (ME) of the adult intestine consists of two layers of visceral smooth muscle (VISM), the inner circular muscle (ICM) and outer longitudinal muscle (OLM), that form sequentially beginning at embryonic day (E) 13 and E15 in the developing mouse. Coordinated contraction of these two layers facilitates the movement of food down the digestive tract. Though abnormal ME function or development has been linked to pseudoobstruction and irritable bowel syndrome, little is known about the molecular character of the smooth muscle that comprises this tissue. We performed transcriptome analysis to identify genes that are enriched in intestinal mesenchyme tissue at E14.5, when the inner circular muscle (ICM) is well established. Results: Expression patterns of enriched

ORGANISM(S): Mus musculus

SUBMITTER: Katherine Gurdziel 

PROVIDER: E-GEOD-74920 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress