Study of gene expression of peripheral blood T lymphocytes from age-series of monozygotic twin couples

ABSTRACT: In this study we analyse a gene expression dataset, obtained by microarray hybridization, consisting of T lymphocytes from 27 healthy monozygotic twin couples with ages ranging over whole adult lifespan (22 to 98 years). This peculiar experimental design, combined with a ridge regression approach, allowed us to define an optimal low-dimensional gene expression signature from which chronological age can be estimated. Our work identified for the first time a group of 125 genes whose expression can be considered a signature of physiologic T cell aging. This signature has been further validated in another dataset of samples of the same cell type, but hybridized over a different platform, showing a significantly good performance that confirmed the power of the chosen analysis design. Moreover,

ORGANISM(S): Homo sapiens

SUBMITTER: Daniel Remondini 

PROVIDER: E-GEOD-74937 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress