Microarray profiles of radiation response in the NCI60 cell lines

ABSTRACT: The 60 cell lines of the NCI Anti-Cancer Drug Screen (NCI60) constitute the most extensively characterized in vitro cancer cell model, and have been tested for sensitivity to over 100,000 potential chemotherapy agents. We have used the NCI60 cell lines and three additional lymphoblast lines to develop a database of responses of cancer cells to ionizing radiation. We compared clonogenic survival, apoptosis induction, and gene expression response by microarray analysis. While several studies have measured relative basal gene expression in the NCI60, this is the first comparison of large-scale gene expression changes in response to genotoxic stress. We found genes differentially regulated in cells with low survival after 2 or 8 Gy γ-rays. In contrast to reported basal gene expression pa

ORGANISM(S): Homo sapiens

SUBMITTER: Sally Amundson 

PROVIDER: E-GEOD-7505 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress