Genome-wide DNA methylation analysis of breast cancer

ABSTRACT: Aberrant DNA methylation is frequently observed in breast cancer. However, the relationship between methylation patterns and the heterogeneity of breast cancer has not been comprehensively characterized. Whole-genome DNA methylation analysis using 450K Illumina BeadArrays was performed on 188 human breast tumors. Unsupervised bootstrap consensus clustering was performed to identify DNA methylation epigenetic subgroups (epitypes). The Cancer Genome Atlas data, incluing methylation profiles of 669 human breast tumors, was utilized for validation. The identified epitypes were characterized by integration with publicly available genome-wide data, including gene expression levels, DNA copy numbers, whole-exome sequencing data, and chromatin states. We identified seven breast cancer epityp

ORGANISM(S): Homo sapiens

SUBMITTER: Markus Ringner 

PROVIDER: E-GEOD-75067 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress