Transcription profiling of human dendritic cells and monocytes treated with anti-FcgRIIb

ABSTRACT: The ability of dendritic cells (DCs) to activate immunity is linked to their maturation status. In prior studies we have shown that selective antibody-mediated blockade of inhibitory FcgRIIB receptor on human DCs in the presence of activating immunoglobulin (Ig) ligands leads to DC maturation and enhanced immunity to antibody-coated tumor cells. Here we show that Fcg receptor (FcgR) mediated activation of human monocytes and monocyte-derived DCs is associated with a distinct gene expression pattern, including several inflammation associated chemokines as well as type 1 interferon (IFN) response genes including the activation of signal transducer and activator of transcription 1 (STAT1). Experiment Overall Design: To further characterize FcgR mediated enhancement of DC function, we analyze

ORGANISM(S): Homo sapiens

SUBMITTER: Kavita Dhodapkar 

PROVIDER: E-GEOD-7509 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress