Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Nir Yosef
PROVIDER: E-GEOD-75107 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Cell 20151119 6
Extensive cellular heterogeneity exists within specific immune-cell subtypes classified as a single lineage, but its molecular underpinnings are rarely characterized at a genomic scale. Here, we use single-cell RNA-seq to investigate the molecular mechanisms governing heterogeneity and pathogenicity of Th17 cells isolated from the central nervous system (CNS) and lymph nodes (LN) at the peak of autoimmune encephalomyelitis (EAE) or differentiated in vitro under either pathogenic or non-pathogeni ...[more]