Leukocyte-Specific Protein1 Regulates T Cell Migration in Rheumatoid Arthritis

ABSTRACT: Copy number variations (CNVs) have been implicated in human diseases. However, it remains unclear how they affect immune dysfunction and autoimmune diseases, including rheumatoid arthritis (RA). Here, we identified a novel LSP1 deletion variant for RA susceptibility located in 11p15.5. We replicated that the copy number of LSP1 is significantly lower in RA patients, which correlates positively with LSP1 protein expression levels. Differentially expressed genes in Lsp1-deficient primary T cells represent cell motility and immune and cytokine responses. Functional assays demonstrated that LSP1, induced by T cell receptor activation, negatively regulates T cell migration by reducing ERK activation in vitro. In mice with T cell-dependent chronic inflammation, loss of Lsp1 promotes migration of

ORGANISM(S): Mus musculus

SUBMITTER: Ji-Hwan Park 

PROVIDER: E-GEOD-75123 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress