A metabolic co-regulator bioinformatics screen reveals that PGC1α suppresses prostate cancer metastasis

ABSTRACT: The current view of cellular transformation and cancer progression supports the notion that cancer cells must reprogram their metabolism in order to survive and progress in different microenvironments. Master co-regulators of metabolism orchestrate the modulation of multiple metabolic pathways through transcriptional programs, and hence constitute a probabilistically parsimonious mechanism for general metabolic rewiring. Here we show that the transcriptional co-activator PGC1α suppresses prostate cancer progression and metastasis. A metabolic co-regulator data mining analysis unveiled that PGC1α is consistently down-regulated in multiple prostate cancer patient datasets and its alteration is associated with reduced disease-free survival and metastasis. Genetically engineered mouse model

ORGANISM(S): Homo sapiens

SUBMITTER: Verónica Torrano Moya 

PROVIDER: E-GEOD-75193 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress