Dehydration impaired normal renal development in infant mice

ABSTRACT: The kidney is a major organ in which fluid balance and waste excretion is regulated. To obtain mature functions of the kidney, normal renal developmental processes need to be preceded. Comprehensive genetic programs underlying renal development during prenatal life have been widely studied. However, postnatal renal development, from infancy to juvenile period, have not been studied yet. Here, we investigated if structural and functional kidney development was still undergoing in early life by analyzing renal transcriptional networks of infant (4 weeks old) and juvenile (7 weeks old) mice. We further examined the effects of dehydration on kidney development. Kidneys at 4 weeks and 7 weeks old showed significantly distinctive functional network of genes. Gene sets related to cell cycle regul

ORGANISM(S): Mus musculus

SUBMITTER: Chong-Su Kim 

PROVIDER: E-GEOD-75604 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress