Early regulation of profibrotic genes in primary human cardiac myocytes by Trypanosoma cruzi

ABSTRACT: The molecular mechanisms of Trypanosoma cruzi induced cardiac fibrosis remains to be elucidated. Primary human cardiomyoctes (PHCM) exposed to invasive T. cruzi trypomastigotes were used for transcriptome profiling and downstream bioinformatic analysis to determine fibrotic-associated genes regulated early during infection process (0 to 120 minutes). The identification of early molecular host responses to T. cruzi infection can be exploited to delineate important molecular signatures that can be used for the classification of Chagasic patients at risk of developing heart disease. Our results show distinct gene network architecture with multiple gene networks modulated by the parasite with an incline towards progression to a fibrogenic phenotype. Early during infection, T. cruzi significant

ORGANISM(S): Homo sapiens

SUBMITTER: Pius Nde 

PROVIDER: E-GEOD-75821 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress