Transcriptomics Responses to Hypoxia and Ketamine in Ovine Fetal Cerebral Cortex

ABSTRACT: Transient hypoxia in pregnancy stimulates a physiological reflex response that redistributes blood flow and defends oxygen delivery to the fetal brain. The chemoreceptor reflex that is responsible for this physiological response is dependent on glutamatergic neurotransmission which, in times of vigorous activity, could produce cell death secondary to calcium uptake. We designed the present experiment to test the hypotheses that transient hypoxia produces damage of the cerebral cortex and that ketamine, an antagonist of NMDA receptors, reduces the damage. Late-gestation, chronically catheterized fetal sheep were subjected to a 30 min period of ventilatory hypoxia that decreased fetal PaO2 from 17±1 to 10±1 mm Hg, or normoxia (PaO2 17±1 mm Hg), with or without pretreatment (10 min befo

ORGANISM(S): Ovis aries

SUBMITTER: Charles Wood 

PROVIDER: E-GEOD-76110 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress