Changes in transcriptome during excisional cutaneous murine wound healing

ABSTRACT: Using microarray analysis, we explored the differences in gene expression in wounded and intact skin using murine model. Injured skin samples were examined at days 1 and 4 post injury. The results provide the detailed molecular profile of the the genetic response to injury. Two full-thickness dermal wounds were made on the opposite sides of the midline of each mouse using a 4 mm punch biopsy instrument. Wounds were made through the epidermis, dermis, and subcutaneous tissue layers while leaving the fascia intact. At a specified time point after the wounding (1 and 4 days), mice were sacrificed by carbon dioxide inhalation. The wounds and surrounding tissues or intact skin samples were removed with an 8 mm biopsy punch.

ORGANISM(S): Mus musculus

SUBMITTER: Evgeniy Riabenko 

PROVIDER: E-GEOD-76144 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress