Expression Profiles of Monozygotic Twin

ABSTRACT: The expression level for 15 887 transcripts in lymphoblastoid cell lines from 19 monozygotic twin pairs (10 male, 9 female) were analysed for the effects of genotype and sex. On an average, the effect of twin pairs explained 31% of the variance in normalized gene expression levels, consistent with previous broad sense heritability estimates. The effect of sex on gene expression levels was most noticeable on the X chromosome, which contained 15 of the 20 significantly differentially expressed genes. A high concordance was observed between the sex difference test statistics and surveys of genes escaping X chromosome inactivation. Notably, several autosomal genes showed significant differences in gene expression between the sexes despite much of the cellular environment differences being effe

ORGANISM(S): Homo sapiens

SUBMITTER: Nicholas Matigian 

PROVIDER: E-GEOD-7624 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress