Integration of ATAC-seq and RNA-seq Identifies Human Alpha Cell and Beta Cell Signature Genes

ABSTRACT: Objective: Although glucagon-secreting α-cells and insulin-secreting β-cells have opposing functions in regulating plasma glucose levels, the two cell types share a common developmental origin and have overlaps in their transcriptome and epigenome profiles. Notably, destruction of one of these cell populations can stimulate repopulation via transdifferentiation of the other cell type, at least in mice, suggesting plasticity between these cell fates. Furthermore, dysfunction of both α- and β-cells contributes to the pathophysiology of type 1 and type 2 diabetes, and β-cell de-differentiation has been proposed to contribute to type 2 diabetes. Our objective was to delineate the molecular properties that maintain islet cell type specification yet allow for cellular plasticity. We hypoth

ORGANISM(S): Homo sapiens

SUBMITTER: Paul Wang 

PROVIDER: E-GEOD-76268 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress