Evaluation of expression quantitative trait loci within two interacting blood pressure quantitative trait loci

ABSTRACT: Genetic dissection of the S rat genome has provided strong evidence for the presence of two interacting blood pressure (BP) quantitative trait loci (QTLs), termed QTL1 and QTL2, on rat chromosome 5. However, the identities of the underlying interacting genetic factors remain unknown. Further experiments targeted to identify the interacting genetic factors by the substitution mapping approach alone are difficult because of the interdependency of natural recombinations to occur at the two QTLs. We hypothesized that the interacting genetic factors underlying these two QTLs may interact at the level of gene transcription and thereby represent expression QTLs (eQTLs). To detect these interacting eQTLs, a custom QTL chip containing the annotated genes within QTL1 and QTL2 was developed and use

ORGANISM(S): Rattus norvegicus

SUBMITTER: Bina Joe 

PROVIDER: E-GEOD-7628 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress