Gene expression signature predicts induction treatment response and clinical outcome in adult Colombian patients with B-acute lymphoblastic leukemia

ABSTRACT: Background. B-Acute lymphoblastic leukemia (B-ALL) represents a hematologic malignancy with poor clinical outcome and low survival rates in adult patients. Only 61% of Colombian adult patients with ALL achieve complete remission and a median overall survival of less than 11.3 months and event-free survival of 7.34 months. Identification of prognostic factors is crucial for proper treatment strategies and optimal results of therapy. The goal of our study was to determine if gene expression signatures correlate with response to therapy and to evaluate the utility of these as prognostic tools for survival to better predict patient risk prior to therapy. Methods and findings. This study included 43 adult patients newly diagnosed with B-cell precursor or common B-ALL. Through microarray gene e

ORGANISM(S): Homo sapiens

SUBMITTER: Jovanny Zabaleta 

PROVIDER: E-GEOD-76349 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress