Tip60 HAT action mediates environmental enrichment induced cognitive restoration

ABSTRACT: Environmental enrichment (EE) conditions have profound beneficial effects for reinstating cognitive ability in neuropathological disorders like Alzheimer’s disease (AD). While EE benefits involve epigenetic gene control mechanisms that comprise histone acetylation, the histone acetyltransferases (HATs) involved remain largely unknown. Here, we examine a role for Tip60 HAT action in mediating activity- dependent beneficial neuroadaptations to EE using the Drosophila CNS mushroom body (MB) as a well-characterized cognition model. We show that flies raised under EE conditions display enhanced MB axonal outgrowth, synapse protein production, histone acetylation induction and transcriptional activation of cognition linked genes when compared to their genotypically identical siblings rais

ORGANISM(S): Drosophila melanogaster

SUBMITTER: Songjun Xu 

PROVIDER: E-GEOD-76612 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress