Tumour sampling method can significantly influence gene expression profiles derived from neoadjuvant window studies I

ABSTRACT: Background: Gene expression profiling has been used extensively within breast cancer research. Patient matched transcriptomic studies of tumour samples before and after treatment offer great potential and have been initiated, but tend not to include a control group. Here we examine gene expression changes between patient-matched core biopsies and surgical resection samples in the absence of treatment, to consider sampling methods and tumour heterogeneity. Patients and Methods: Illumina BeadArray technology was used to measure dynamic changes in gene expression from thirty-seven paired baseline and surgically excised breast tumour samples obtained from women receiving no treatment prior to surgery. Results: Patient-matched sample pairs had significantly higher correlations than samples

ORGANISM(S): Homo sapiens

SUBMITTER: Dominic Pearce 

PROVIDER: E-GEOD-76726 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress