Targeted deletion of circadian clock gene Arntl in the nephron results in dysregulation of diverse metabolic pathways

ABSTRACT: The circadian clock controls a wide variety of metabolic and homeostatic processes in a number of tissues, including the kidney. However, the role of the renal circadian clocks remains largely unknown. To address this question we performed transcriptomic analysis in mice with inducible and conditional ablation of the circadian clock system in the renal tubular cells (Bmal1lox/lox/Pax8-rtTA/LC1 mice). Deep sequencing of the renal transcriptome revealed significant changes in the expression of genes related to metabolic pathways and organic anion transport. In parallel, kidneys from Bmal1lox/lox/Pax8-rtTA/LC1 mice exhibited a significant decrease in the NAD+/NADH ratio suggesting an increased anaerobic glycolysis and/or decreased mitochondrial function. In-depth analysis of two selected path

ORGANISM(S): Mus musculus

SUBMITTER: Sylvain Pradervand 

PROVIDER: E-GEOD-76838 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress