Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Sajeev Batra
PROVIDER: E-GEOD-7684 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
The Journal of experimental medicine 20070423 5
Francisella tularensis is a pathogenic bacterium whose virulence is linked to its ability to replicate within the host cell cytosol. Entry into the macrophage cytosol activates a host-protective multimolecular complex called the inflammasome to release the proinflammatory cytokines interleukin (IL)-1beta and -18 and trigger caspase-1-dependent cell death. In this study, we show that cytosolic F. tularensis subspecies novicida (F. novicida) induces a type I interferon (IFN) response that is essen ...[more]