Transcription profiling of mouse growth plate chondrocyte differentiation yields insight into endochondral ossification

ABSTRACT: A variety of cell cultures models and in vivo approaches have been used to study gene expression during chondrocyte differentiation. The extent to which the in vitro models reflect bona fide gene regulation in the growth plate has not been quantified. In addition, studies that evaluate global gene expression changes among different growth plate zones are limited. To address these issues, we completed a microarray screen of three growth plate zones derived from manually segmented embryonic mouse tibiae. Classification of genes differentially expressed between each respective growth plate zone, functional categorization as well as characterization of gene expression patterns, cytogenetic loci, signaling pathways and functional motifs confirmed documented data and pointed to novel aspects

ORGANISM(S): Mus musculus

SUBMITTER: Claudine James 

PROVIDER: E-GEOD-7685 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress