The YY1/MMP2 axis promotes trophoblast invasion at the maternal-fetal interface

ABSTRACT: YY1 is a sequence-specific DNA-binding transcription factor that has many important biological roles. However, its function in trophoblasts at the maternal-foetal interface remains to be elucidated. In this study, we used an mRNA microarray and quantitative reverse transcription-PCR and compared the YY1 mRNA expression level in trophoblasts between patients with recurrent miscarriage (RM) and healthy control subjects. Our results revealed that YY1 mRNA expression was significantly lower in the trophoblasts of the RM group compared with the healthy control group. Furthermore, immunofluorescence and immunohistochemical data showed that YY1 was highly expressed in human placental villi during early pregnancy, especially in cytotrophoblast cells and invasive extravillous trophoblasts, and it w

ORGANISM(S): Homo sapiens

SUBMITTER: Fu-Ju Tian 

PROVIDER: E-GEOD-76862 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress