CENP-A Deposition Defines Sequences for Retention and Elimination during Programmed DNA Elimination in Nematode

ABSTRACT: Organisms invest significant effort into maintaining genome stability. However, in diverse groups of eukaryotes, portions or entire chromosomes are lost in early development or during sex determination, a process known as programmed DNA elimination. Little is known about how different segments of the genome are reproducibly retained and discarded during programmed DNA elimination. We tested the hypothesis that selective retention is mediated by regulation of centromere-mediated association of chromosome segments with the mitotic spindle. We report that on the holocentric chromosomes of the nematode Ascaris, the core centromeric histone CENP-A is localized differently in cells undergoing DNA elimination from those undergoing germline mitosis. Prior to DNA elimination, CENP-A is significant

ORGANISM(S): Ascaris suum

SUBMITTER: Jianbin Wang 

PROVIDER: E-GEOD-76914 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress