Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Scott Tomlins
PROVIDER: E-GEOD-7702 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Nature 20070801 7153
Recently, we identified recurrent gene fusions involving the 5' untranslated region of the androgen-regulated gene TMPRSS2 and the ETS (E26 transformation-specific) family genes ERG, ETV1 or ETV4 in most prostate cancers. Whereas TMPRSS2-ERG fusions are predominant, fewer TMPRSS2-ETV1 cases have been identified than expected on the basis of the frequency of high (outlier) expression of ETV1 (refs 3-13). Here we explore the mechanism of ETV1 outlier expression in human prostate tumours and prosta ...[more]