Chromatin interactions involving super-enhancers associate with specific expression patterns of target genes

ABSTRACT: Super-enhancers may regulate target genes through chromatin looping. We connected super-enhancers in the K562 chronic myelogenous leukemia cell line with chromatin interactions identified from Chromatin Interaction Analysis with Paired-End Tag (ChIA-PET) data. Gene expression at proximal elements that are connected with distal super-enhancers showed significantly higher cell-type specificity than at proximal elements connected with other elements or not involved in interaction. 4C and Episwitch analysis of chromatin interactions showed that certain chromatin interactions are cell-specific, but others are more general. While super-enhancers upstream of c-MYC at the MYC-335 element can be found in other cancers, only super-enhancers downstream of c-MYC can be found in K562. 4C analysis of th

ORGANISM(S): Homo sapiens

SUBMITTER: Melissa Fullwood 

PROVIDER: E-GEOD-77125 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress