MicroRNA-7-5p inhibits melanoma cell proliferation and metastasis by suppressing RelA

ABSTRACT: microRNA-7-5p (miR-7-5p) is an established tumor suppressor in multiple cancer types and inhibits growth and invasion by suppressing expression and activity of the epidermal growth factor receptor (EGFR) signaling pathway. While melanoma is not typically driven by EGFR signaling, expression of miR-7-5p is reduced in metastatic tumors compared to primary melanoma. Here, we investigated the biological and clinical significance of miR-7-5p in melanoma. Our results showed that augmenting miR-7-5p expression in vitro markedly reduced tumor cell viability, colony formation and induced cell cycle arrest. Furthermore, ectopic expression of miR-7-5p reduced migration and invasion of melanoma cells in vitro and reduced melanoma lung colonizationmetastasis in vivo. To investigate the mechanism underl

ORGANISM(S): Homo sapiens

SUBMITTER: Patrick Candy 

PROVIDER: E-GEOD-77196 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress