Gene expression profiling in primary human skeletal myotubes with small molecule inhibitors of lipid accumulation

ABSTRACT: The development of insulin resistance is strongly associated with accumulation of intracellular lipid in tissues outside of adipose including skeletal muscle, liver and heart. In obese humans, intramyocellular lipid (IMCL) is negatively correlated with whole body insulin sensitivity. The skeletal myocyte imports fatty acids (FA) into the cell from circulating free fatty acids or lipoprotein particles such as VLDL, to support energy production. Once transported into the cell, FAs are oxidized for ATP production, used to build membranes, or stored as triglyceride. However, in the long term, increased delivery of fatty acids can exceed mitochondrial oxidative capacity and set the stage for a vicious cycle of cellular lipotoxicity. We have recently identified a novel small molecule inhibitor o

ORGANISM(S): Homo sapiens

SUBMITTER: Rick Vega 

PROVIDER: E-GEOD-77212 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress