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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Systematic Evaluation Of Genes And Genetic Variants Associated With Type 1 Diabetes Susceptibility

ABSTRACT: Application of Systems Genetics analysis for systematic evaluation of candidate causal genes associated with risk of Type 1 Diabetes along with follow-up bioinformatics pathway analysis. Total RNA obtained from whole blood (for EBV-B cells) and Peripheral blood mononuclear cells (PBMCs) (for T-cells)

ORGANISM(S): Homo sapiens

SUBMITTER: Ramesh Ram

PROVIDER: E-GEOD-77350 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Systematic Evaluation of Genes and Genetic Variants Associated with Type 1 Diabetes Susceptibility.

Ram Ramesh R Mehta Munish M Nguyen Quang T QT Larma Irma I Boehm Bernhard O BO Pociot Flemming F Concannon Patrick P Morahan Grant G

Journal of immunology (Baltimore, Md. : 1950) 20160224 7

Genome-wide association studies have found >60 loci that confer genetic susceptibility to type 1 diabetes (T1D). Many of these are defined only by anonymous single nucleotide polymorphisms: the underlying causative genes, as well as the molecular bases by which they mediate susceptibility, are not known. Identification of how these variants affect the complex mechanisms contributing to the loss of tolerance is a challenge. In this study, we performed systematic analyses to characterize these var ...[more]

PMID: 26912320

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