In vivo genome-wide profiling reveals a tissue-specific role for 5-formylcytosine

ABSTRACT: Background: Genome-wide methylation of cytosine can be modulated in the presence of TET and thymine DNA glycosylase (TDG) enzymes. TET enzymes are able to oxidise 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC). TDG can excise the oxidative products 5fC and 5caC, initiating base excision repair. Furthermore, these modified bases are stable and detectable in the genome, raising the possibility that they could have epigenetic functions in their own right. To date, functional investigation of the genome-wide distribution of 5fC has been restricted to cell culture based systems, while its in vivo profile, in particular during development, remains unknown. Results: Here we describe the first analysis of the in vivo genome-wide profi

ORGANISM(S): Mus musculus

SUBMITTER: Dario Beraldi 

PROVIDER: E-GEOD-77447 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress