Transcription profiling of human colon cancer cell line HCT116 expressing miR-43a vs. controls to investigate miR-43a induced gene expression

ABSTRACT: In order to examine the consequences of human miR-34a induction on the transcriptome, HCT116 cells (a colon cancer cell line) were infected with a retrovirus that produces miR-34a. Gene expression profiles were then monitored using Affymetrix microarrays. Affymetrix microarrays were used to examine the transcriptomes of HCT116 cells infected with an empty retroviral vector (pMSCV-PIG) or a retroviral vector that expresses human miR-34a. Experiment Overall Design: RNA from retrovirally-infected cells was isolated and hybridized to Affymetrix microarrays.

ORGANISM(S): Homo sapiens

SUBMITTER: Joshua Mendell 

PROVIDER: E-GEOD-7754 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress