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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Expression data from mouse adrenal glands extracted from wild-type and sf1:Cre; Prkar1a Fl/Fl (KO) adrenals

ABSTRACT: Prkar1a encodes one of the regulatory subunits of PKA. Prkar1a gene ablation in the adrenal cortex is associated with profound phenotypic alterations, constitutive PKA activation and reciprocal inhibition of WNT signallilng pathway We used microarrays to analyse gene expression in response to Prkar1a gene ablation Adrenal glands were dissected from KO (4) and wild-type littermate (4) mice

ORGANISM(S): Mus musculus

SUBMITTER: Pierre Val

PROVIDER: E-GEOD-77630 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Expression data from mouse adrenal glands extracted from wild-type and sf1:Cre; Prkar1a Fl/Fl (KO) adrenals

Project description:Prkar1a encodes one of the regulatory subunits of PKA. Prkar1a gene ablation in the adrenal cortex is associated with profound phenotypic alterations, constitutive PKA activation and reciprocal inhibition of WNT signallilng pathway We used microarrays to analyse gene expression in response to Prkar1a gene ablation

2016-02-06 | GSE77630 | GEO

Expression data from mouse adrenal glands extracted from wild-type (WT) and Cyp11b2tm1.1(cre)Brlt;Prkar1afl/fl(KO) adrenals

Project description:We demonstrate that PKA signalling drives zonal conversion within adult adrenocortical lineage in a sexually dimorphic manner. Our data establish that Prkar1a genetic ablation (leading to constitutive PKA activation) in the adult adrenocortical lineage leads to endocrine hyperactivity and accelerates adrenal cortex renewal. This results in increased zona fasciculata differentiation and final conversion into reticularis-like zone. This phenomenon relies partly on sex-dependent mechanisms of cortical renewal, on which the male androgenic milieu exerts a repressive action through induction of WNT signalling, which in turn antagonizes PKA signalling and cortical cell turnover. We used microarrays to analyse gene expression in response to Prkar1a gene ablation in the adult adrenocortical cell lineage in both female and male mice and explored the effects of orchidectomy (GDX).

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Expression data from 2-week and 2-month-old mouse testes extracted from wild-type (WT), Sf1:Cre,Prkar1afl/fl (prKO), Amh:Cre,Prkar1afl/fl (srKO), Cyp11a1:Cre,Prkar1afl/fl (lrKO).

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Expression data from mouse adrenal glands extracted from wild-type and sf1:Cre; Ezh2 Fl/Fl (KO) adrenals

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Activation of cyclic AMP signaling leads to different pathway alterations in lesions of the adrenal cortex caused by germline PRKAR1A defects versus those due to somatic GNAS mutations

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Human Adrenal Cortex affected by Primary Pigmented Nodular Adrenocortical Disease

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2005-03-10 | E-GEOD-2055 | biostudies-arrayexpress

Human Adrenal Cortex affected by Primary Pigmented Nodular Adrenocortical Disease

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