STAT5 paralog dose governs T cell effector and regulatory function

ABSTRACT: The transcription factor STAT5 is fundamental to the mammalian immune system. However, the relationship between its two paralogs, STAT5A and STAT5B, and the extent to which they are functionally distinct, remains controversial. We addressed this longstanding question in primary CD4+ 'helper' T cells, the principal orchestrators of adaptive immunity. Using a combination of genetic and genomic approaches, we demonstrate that, although both influence regulatory (Treg) and effector T cell responses, and control many of the same genes, they are not functionally equivalent and, in fact, only the latter is required for immunological tolerance. Differences in genomic distribution and transcriptomic output support the conclusion that STAT5B is dominant and, surprisingly, point towards relative abun

ORGANISM(S): Mus musculus

SUBMITTER: Yuka Kanno 

PROVIDER: E-GEOD-77656 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress